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Version: 17.06d (Release date: 2017-06-26)
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IL4-Pseudomonas Exotoxin Fusion Protein MDNA55 (Code C79843)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: IL4-Pseudomonas Exotoxin Fusion Protein MDNA55

Definition: A fusion protein consisting of the cytokine interleukin-4 (IL-4) linked to a truncated form of Pseudomonas exotoxin with potential antineoplastic activity. Upon specific, high-affinity binding to IL-4 receptors located on the tumor cell surface., IL4-Pseudomonas exotoxin fusion protein MDNA55 is internalized; the exotoxin moiety then binds to translation elongation factor 2 (EF-2), which may result in ADP ribosylation, deactivation of EF-2, inhibition of protein synthesis, and tumor cell apoptosis. The Pseudomonas exotoxin moiety of this agent has been engineered to reduce non-specific binding to cells expressing its receptor, the multiligand cell surface receptor alpha 2-macroglobulin receptor/low-density lipoprotein receptor-related protein (alpha 2MR/LRP). IL-4R is a type I transmembrane protein that binds IL-4 and IL-13 and may be overexpressed by cancers such as renal cell carcinoma and glioma.

Label: IL4-Pseudomonas Exotoxin Fusion Protein MDNA55

NCI Thesaurus Code: C79843 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388450  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL4-PE
IL4-Pseudomonas Exotoxin Fusion Protein MDNA55
INxin
MDNA55
PRX-321
PRX321

External Source Codes: 
PDQ Closed Trial Search ID 630680
PDQ Open Trial Search ID 630680 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388450

Other Properties:
     Name Value (qualifiers indented underneath)
code C79843
Legacy_Concept_Name IL4-Pseudomonas_Exotoxin_Fusion_Protein_PRX321
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79843

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