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Version: 17.06d (Release date: 2017-06-26)
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Talmapimod (Code C79841)

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Terms & Properties

Preferred Name: Talmapimod

Definition: An orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins.

Label: Talmapimod

NCI Thesaurus Code: C79841 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541463  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-indole-3-acetamide, 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1- piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-
2-[6-Chloro-5-[[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl]-1- methyl-1H-indol-3-yl]-N,N-dimethyl-2-oxoacetamide
SCIO 469
TALMAPIMOD
Talmapimod

External Source Codes: 
CAS Registry Number 309913-83-5 (see NLM ChemIDplus info)
FDA UNII Code B1E00KQ6NT
PDQ Closed Trial Search ID 387795
PDQ Open Trial Search ID 387795 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541463

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H30ClFN4O3
code C79841
Contributing_Source FDA
Legacy_Concept_Name Talmapimod
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79841

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