skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Talmapimod (Code C79841)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Talmapimod

Definition: An orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins.

Label: Talmapimod

NCI Thesaurus Code: C79841 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541463  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-indole-3-acetamide, 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1- piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-
2-[6-Chloro-5-[[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl]-1- methyl-1H-indol-3-yl]-N,N-dimethyl-2-oxoacetamide
SCIO 469

External Source Codes: 
CAS Registry Number 309913-83-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 387795
PDQ Open Trial Search ID 387795 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541463

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H30ClFN4O3
code C79841
Contributing_Source FDA
Legacy_Concept_Name Talmapimod
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom