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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Inhibitor XL888 (Code C79835)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor XL888

Definition: An orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met.

Display Name: Hsp90 Inhibitor XL888

Label: Hsp90 Inhibitor XL888

NCI Thesaurus Code: C79835 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388445  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Heat Shock Protein 90 Inhibitor XL888
Hsp90 Inhibitor XL888
XL888

External Source Codes: 
PDQ Closed Trial Search ID 629922
PDQ Open Trial Search ID 629922 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388445

Other Properties:
     Name Value (qualifiers indented underneath)
code C79835
Contributing_Source CTRP
Legacy_Concept_Name Hsp90_Inhibitor_XL888
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79835

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