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Version: 17.06d (Release date: 2017-06-26)
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Light-Emitting Oncolytic Vaccinia Virus GL-ONC1 (Code C79833)

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Terms & Properties

Preferred Name: Light-Emitting Oncolytic Vaccinia Virus GL-ONC1

Definition: An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent and antineoplastic activities. Upon administration, light-emitting oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor vasculature. Once inside the cell, the virus replicates, resulting in tumor cell lysis and the release of mature viral particles into the tumor microenvironment. Released viral particles may then infect and destroy neighboring tumor cells. In addition, the release of tumor-associated antigens (TAAs) by lysed tumor cells into the bloodstream may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against the tumor. The expression of RUC-GFP by this agent allows for both detection and monitoring of virally infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence imaging and fluorescence imaging techniques.

Display Name: Light-Emitting Oncolytic Vaccinia Virus GL-ONC1

Label: Light-Emitting Oncolytic Vaccinia Virus GL-ONC1

NCI Thesaurus Code: C79833 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388438  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Light-Emitting Oncolytic Vaccinia Virus GL-ONC1

External Source Codes: 
PDQ Closed Trial Search ID 629379
PDQ Open Trial Search ID 629379 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C79833
Contributing_Source CTRP
Legacy_Concept_Name Light-Emitting_Oncolytic_Vaccinia_Virus_GL-ONC1
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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