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Version: 17.06d (Release date: 2017-06-26)
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Masitinib Mesylate (Code C79831)

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Terms & Properties

Preferred Name: Masitinib Mesylate

Definition: The orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).

Display Name: Masitinib Mesylate

Label: Masitinib Mesylate

NCI Thesaurus Code: C79831 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2351399  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide Mesylate
AB1010
Masitinib Mesylate

External Source Codes: 
PDQ Closed Trial Search ID 629109
PDQ Open Trial Search ID 629109 (check for NCI PDQ open clinical trial info)
UMLS CUI C2351399

Other Properties:
     Name Value (qualifiers indented underneath)
code C79831
Contributing_Source CTRP
Legacy_Concept_Name Masitinib_Mesylate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79831

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