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Version: 17.06d (Release date: 2017-06-26)
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Irosustat (Code C79827)

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Terms & Properties

Preferred Name: Irosustat

Definition: Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells, such as those of the breast, ovary, and endometrium. STS is a cytoplasmic enzyme responsible for the conversion of circulating inactive estrone sulfate and estradiol sulfate to biologically active unconjugated estrone and estradiol, respectively.

Display Name: Irosustat

Label: Irosustat

NCI Thesaurus Code: C79827 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3853843  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
667 Coumate
Steroid Sulfatase Inhibitor BN 83495
STX 64

External Source Codes: 
CAS Registry Number 288628-05-7 (see NLM ChemIDplus info)
FDA UNII Code 366037O6O7
PDQ Closed Trial Search ID 626715
PDQ Open Trial Search ID 626715 (check for NCI PDQ open clinical trial info)
UMLS CUI C3853843

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C14H15NO5S
code C79827
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Steroid_Sulfatase_Inhibitor_BN_83495
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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