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Version: 16.10e (Release date: 2016-10-31)
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Adenosine A3 Receptor Agonist CF102 (Code C79826)

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Terms & Properties

Preferred Name: Adenosine A3 Receptor Agonist CF102

Definition: An orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.

Label: Adenosine A3 Receptor Agonist CF102

NCI Thesaurus Code: C79826 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0289969  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide
2-Cl-IB-MECA
A3AdR Agonist CF102
Adenosine A3 Receptor Agonist CF102
Adenosine Receptor A3 Agonist CF102
C-Ibza-MU
CF102

External Source Codes: 
CAS Registry Number 163042-96-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 626663
PDQ Open Trial Search ID 626663 (check for NCI PDQ open clinical trial info)
UMLS CUI C0289969

Other Properties:
Name Value (qualifiers indented underneath)
code C79826
Legacy_Concept_Name Adenosine_A3_Receptor_Agonist_CF102
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79826

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