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Version: 17.06d (Release date: 2017-06-26)
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Olaratumab (Code C79825)

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Terms & Properties

Preferred Name: Olaratumab

Definition: A fully human IgG1 monoclonal antibody directed against the platelet-derived growth factor receptor alpha (PDGFR alpha) with potential antineoplastic activity. Anti-PDGFR alpha monoclonal antibody IMC-3G3 selectively binds to PDGFR alpha, .blocking the binding of its ligand, PDGF; signal transduction downstream of PDGFR through the MAPK and PI3K pathways is inhibited, which may result in inhibition of angiogenesis and tumor cell proliferation. Overexpressed by various cancer cell types, PDGFR is a transmembrane protein tyrosine kinase receptor, consisting of isoforms A and B that is important in regulating cellular growth and differentiation and angiogenesis.

NCI-GLOSS Definition: A substance being studied in the treatment of glioblastoma (a type of brain tumor) that has come back. It binds to receptors for a protein called platelet-derived growth factor (PDGF). This keeps PDGF from binding to the cells. This may stop the growth of cancer cells and blood vessels that have the receptors for PDGF. It is a type of monoclonal antibody.

Display Name: Olaratumab

Label: Olaratumab

NCI Thesaurus Code: C79825 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703171  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-PDGFR alpha monoclonal antibody IMC-3G3
Anti-PDGFR alpha Monoclonal Antibody IMC-3G3
anti-platelet-derived growth factor receptor alpha monoclonal antibody IMC-3G3
Anti-Platelet-Derived Growth Factor Receptor alpha Monoclonal Antibody IMC-3G3
IMC-3G3
Lartruvo
Olaratumab
OLARATUMAB

External Source Codes: 
CAS Registry Number 1024603-93-7 (see NLM ChemIDplus info)
FDA UNII Code TT6HN20MVF
PDQ Closed Trial Search ID 626630
PDQ Open Trial Search ID 626630 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703171

Other Properties:
     Name Value (qualifiers indented underneath)
code C79825
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-PDGFR_alpha_Monoclonal_Antibody_IMC-3G3
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79825

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