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Version: 17.06d (Release date: 2017-06-26)
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Defactinib (Code C79809)

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Terms & Properties

Preferred Name: Defactinib

Definition: An orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Defactinib inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including those involving RAS/MEK/ERK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation, survival, and tumor angiogenesis. The tyrosine kinase FAK, a signal transducer for integrins, is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types.

Display Name: Defactinib

Label: Defactinib

NCI Thesaurus Code: C79809 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3899400  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl)amino)-5-(trifluoromethyl)-2-pyrimidinyl)amino)-

External Source Codes: 
CAS Registry Number 1073154-85-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 746096
PDQ Open Trial Search ID 746096 (check for NCI PDQ open clinical trial info)
UMLS CUI C3899400

Other Properties:
     Name Value (qualifiers indented underneath)
code C79809
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name FAK_Inhibitor_PF-04554878
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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