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Version: 17.06d (Release date: 2017-06-26)
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Defactinib (Code C79809)

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Terms & Properties

Preferred Name: Defactinib

Definition: An orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. Defactinib inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including those involving RAS/MEK/ERK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation, survival, and tumor angiogenesis. The tyrosine kinase FAK, a signal transducer for integrins, is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types.

Display Name: Defactinib

Label: Defactinib

NCI Thesaurus Code: C79809 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3899400  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl)amino)-5-(trifluoromethyl)-2-pyrimidinyl)amino)-
Defactinib
DEFACTINIB

External Source Codes: 
CAS Registry Number 1073154-85-4 (see NLM ChemIDplus info)
FDA UNII Code 53O87HA2QU
PDQ Closed Trial Search ID 746096
PDQ Open Trial Search ID 746096 (check for NCI PDQ open clinical trial info)
UMLS CUI C3899400

Other Properties:
     Name Value (qualifiers indented underneath)
code C79809
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name FAK_Inhibitor_PF-04554878
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79809

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