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Version: 16.11d (Release date: 2016-11-28)
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Gemcitabine Elaidate (Code C79803)

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Terms & Properties

Preferred Name: Gemcitabine Elaidate

Definition: A lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase.

Display Name: Gemcitabine Elaidate

Label: Gemcitabine Elaidate

NCI Thesaurus Code: C79803 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703166  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CP-4126
Gemcitabine 5'-Elaidic Acid Ester
Gemcitabine Elaidate
GEMCITABINE ELAIDATE

External Source Codes: 
CAS Registry Number 210829-30-4 (see NLM ChemIDplus info)
FDA UNII Code 231C73W7LG
PDQ Closed Trial Search ID 624375
PDQ Open Trial Search ID 624375 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703166

Other Properties:
Name Value (qualifiers indented underneath)
code C79803
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gemcitabine_5-Elaidic_Acid_Ester
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79803

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