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Version: 17.06d (Release date: 2017-06-26)
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Ad5-CMV-NIS (Code C79800)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ad5-CMV-NIS

Definition: A recombinant type 5 adenovirus (Ad5), encoding the gene for the human sodium-iodide symporter (NIS) linked to the cytomegalovirus (CMV) promoter, with potential gene transfection activity. Upon intratumoral injection, Ad5-CMV-NIS is taken up by tumor cells, resulting in the cellular expression of NIS. Subsequently, orally administered iodine 131 is taken up by NIS-expressing tumor cells, which may result in the selective accumulation of a cytotoxic dose of beta and gamma radiation in non-thyroidal tumor cells, sparing adjacent normal tissue. NIS, an intrinsic membrane glycoprotein, is an ion pump that actively transports iodide into cells which concentrate iodine; in addition to thyroid epithelial cells, it is found in non-thyroidal tissues including the salivary glands, the gastric mucosa, and lactating mammary glands.

Display Name: Ad5-CMV-NIS

Label: Ad5-CMV-NIS

NCI Thesaurus Code: C79800 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL388415  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad5-CMV-NIS

External Source Codes: 
PDQ Closed Trial Search ID 619354
PDQ Open Trial Search ID 619354 (check for NCI PDQ open clinical trial info)
NCI META CUI CL388415

Other Properties:
     Name Value (qualifiers indented underneath)
code C79800
Contributing_Source CTRP
Legacy_Concept_Name Ad5-CMV-NIS
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79800

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