skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Banoxantrone (Code C79528)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Banoxantrone

Definition: A bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone (AQ4N) is converted and activated by cytochrome P450 enzymes, which are upregulated in certain tumors, to the cytotoxic DNA-binding agent AQ4. Banoxantrone intercalates into and crosslinks DNA, and inhibits topoisomerase II. This results in an inhibition of DNA replication and repair in tumor cells. Combined with conventional therapeutic agents, both oxygenic and hypoxic regions of tumors can be targeted.

Display Name: Banoxantrone

Label: Banoxantrone

NCI Thesaurus Code: C79528 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0299316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9,10-Anthracenedione, 1,4-bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-, N,N'-dioxide
Aq4N
AQ 4N
Banoxantrone
BANOXANTRONE

External Source Codes: 
CAS Registry Number 136470-65-0 (see NLM ChemIDplus info)
FDA UNII Code W5H7E45YT3
PDQ Closed Trial Search ID 393464
PDQ Open Trial Search ID 393464 (check for NCI PDQ open clinical trial info)
UMLS CUI C0299316

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H28N4O6
code C79528
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Banoxantrone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C79528

Mainbox Bottom