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Version: 17.06d (Release date: 2017-06-26)
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Quinine (Code C794)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Quinine

Definition: A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Label: Quinine

NCI Thesaurus Code: C794 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0034417  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Quinine
QUIN
QUININE
Quinine

External Source Codes: 
CAS Registry Number 130-95-0 (see NLM ChemIDplus info)
FDA UNII Code A7V27PHC7A
ChEBI ID CHEBI:15854 (see ChEBI info)
NSC Code 192949 (see NCI DTP info)
PDQ Closed Trial Search ID 41253
PDQ Open Trial Search ID 41253 (check for NCI PDQ open clinical trial info)
UMLS CUI C0034417

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H24N2O2
code C794
Contributing_Source FDA
Legacy_Concept_Name Quinine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C794

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