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Version: 17.06d (Release date: 2017-06-26)
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Quinidine (Code C793)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Quinidine

Definition: An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased conduction velocity of nerve impulses. Quinidine exerts its antimalarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the heme polymer (hemazoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite.

Label: Quinidine

NCI Thesaurus Code: C793 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0034414  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
QUINIDINE
Quinidine

External Source Codes: 
CAS Registry Number 56-54-2 (see NLM ChemIDplus info)
FDA UNII Code ITX08688JL
ChEBI ID CHEBI:28593 (see ChEBI info)
PDQ Closed Trial Search ID 39022
PDQ Open Trial Search ID 39022 (check for NCI PDQ open clinical trial info)
UMLS CUI C0034414

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H24N2O2
code C793
Contributing_Source FDA
Legacy_Concept_Name Quinidine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C793

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