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Version: 17.06d (Release date: 2017-06-26)
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Quercetin (Code C792)

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Terms & Properties

Preferred Name: Quercetin

Definition: A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators.

CRCH Definition: A kaempferol with a hydroxyl group at C-3'.

Display Name: Quercetin

Label: Quercetin

NCI Thesaurus Code: C792 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0034392  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one
3,3',4',5,7-Pentahydroxyflavone
C.I. Natural Yellow 10
Quercetin
QUERCETIN

External Source Codes: 
CAS Registry Number 117-39-5 (see NLM ChemIDplus info)
FDA UNII Code 9IKM0I5T1E
ChEBI ID CHEBI:16243 (see ChEBI info)
NSC Code 9219 (see NCI DTP info)
PDQ Closed Trial Search ID 43114
PDQ Open Trial Search ID 43114 (check for NCI PDQ open clinical trial info)
UMLS CUI C0034392

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H10O7
code C792
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Quercetin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance
Unit mg

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C792

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