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Version: 17.08d (Release date: 2017-08-28)
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Dinaciclib (Code C78854)

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Terms & Properties

Preferred Name: Dinaciclib

Definition: A pyrazolo[1,5-a]pyrimidine with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9; inhibition of CDK1 and CDK2 may result in cell cycle repression and tumor cell apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of advanced melanoma (a type of skin cancer) and other types of cancer. It blocks cell division and may cause cancer cells to die. It is a type of cyclin-dependent kinase inhibitor.

Display Name: Dinaciclib

Label: Dinaciclib

NCI Thesaurus Code: C78854 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2698720  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5- a]pyrimidin-5-yl]-, (2S)-
CDK inhibitor SCH 727965
CDK Inhibitor SCH 727965
SCH 727965

External Source Codes: 
CAS Registry Number 779353-01-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 612855
PDQ Open Trial Search ID 612855 (check for NCI PDQ open clinical trial info)
UMLS CUI C2698720

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H28N6O2
code C78854
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name CDK_Inhibitor_SCH_727965
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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