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Version: 17.06d (Release date: 2017-06-26)
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Anti-PD-L1 Monoclonal Antibody MDX-1105 (Code C78852)

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Terms & Properties

Preferred Name: Anti-PD-L1 Monoclonal Antibody MDX-1105

Definition: A fully human monoclonal antibody directed against programmed cell death-1 ligand 1 (PD-L1) with immune checkpoint inhibitory and potential antineoplastic activities. Anti-PD-L1 monoclonal antibody MDX-1105 binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1), which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells.

Display Name: Anti-PD-L1 Monoclonal Antibody MDX-1105

Label: Anti-PD-L1 Monoclonal Antibody MDX-1105

NCI Thesaurus Code: C78852 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387680  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-PD-L1 Monoclonal Antibody MDX-1105
BMS 936559
MDX-1105

External Source Codes: 
PDQ Closed Trial Search ID 612730
PDQ Open Trial Search ID 612730 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387680

Other Properties:
     Name Value (qualifiers indented underneath)
code C78852
Contributing_Source CTRP
Legacy_Concept_Name Anti-PD-L1_Monoclonal_Antibody_MDX-1105
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78852

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