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Version: 17.06d (Release date: 2017-06-26)
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HDAC/EGFR/HER2 Inhibitor CUDC-101 (Code C78850)

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Terms & Properties

Preferred Name: HDAC/EGFR/HER2 Inhibitor CUDC-101

Definition: A multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.

Display Name: HDAC/EGFR/HER2 Inhibitor CUDC-101

Label: HDAC/EGFR/HER2 Inhibitor CUDC-101

NCI Thesaurus Code: C78850 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703140  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CUDC-101
HDAC/EGFR/HER2 Inhibitor CUDC-101

External Source Codes: 
PDQ Closed Trial Search ID 612729
PDQ Open Trial Search ID 612729 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703140

Other Properties:
     Name Value (qualifiers indented underneath)
code C78850
Contributing_Source CTRP
Legacy_Concept_Name HDAC_EGFR_HER2_Inhibitor_CUDC-101
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78850

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