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Version: 17.06d (Release date: 2017-06-26)
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Sonolisib (Code C78848)

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Terms & Properties

Preferred Name: Sonolisib

Definition: A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Sonolisib inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Sonolisib

Label: Sonolisib

NCI Thesaurus Code: C78848 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1566038  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(4E)-4-(((Bis(prop-2-en-1-yl)amino)methylidene)-6-hydroxy-1alpha-(methoxymethyl)-3,7,17-trioxo-2-oxaandrosta-5,8-dien-11alpha-yl Acetate
acetic acid (1S,4E,10R,11R,13S,14R)-4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester
acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha 12-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester
PX-866
PX866
PX 866
Sonolisib
SONOLISIB

External Source Codes: 
CAS Registry Number 502632-66-8 (see NLM ChemIDplus info)
FDA UNII Code 987796874T
PDQ Closed Trial Search ID 612038
PDQ Open Trial Search ID 612038 (check for NCI PDQ open clinical trial info)
UMLS CUI C1566038

Other Properties:
     Name Value (qualifiers indented underneath)
code C78848
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PI3K_Inhibitor_PX-866
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78848

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