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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Inhibitor BIIB028 (Code C78846)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hsp90 Inhibitor BIIB028

Definition: A small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.

Display Name: Hsp90 Inhibitor BIIB028

Label: Hsp90 Inhibitor BIIB028

NCI Thesaurus Code: C78846 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387614  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BIIB028
Hsp90 Inhibitor BIIB028

External Source Codes: 
PDQ Closed Trial Search ID 612037
PDQ Open Trial Search ID 612037 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387614

Other Properties:
     Name Value (qualifiers indented underneath)
code C78846
Contributing_Source CTRP
Legacy_Concept_Name Hsp90_Inhibitor_BIIB02
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78846

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