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Version: 17.06d (Release date: 2017-06-26)
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Tetrodotoxin (Code C78845)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tetrodotoxin

Definition: A neurotoxin with potential analgesic activity. Tetrodotoxin binds to the pores of fast voltage-gated fast sodium channels in nerve cell membranes, inhibiting nerve action potentials and blocking nerve transmission. Although found in various species of fish (such as the pufferfish), newts, frogs, flatworms, and crabs, tetrodotoxin, for which there is no known antidote, is actually produced by bacteria such as Vibrio alginolyticus, Pseudoalteromonas tetraodonis, and other vibrio and pseudomonas bacterial species.

Display Name: Tetrodotoxin

Label: Tetrodotoxin

NCI Thesaurus Code: C78845 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039705  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Tectin
Tetrodotoxin
TTX

External Source Codes: 
ChEBI ID CHEBI:9506 (see ChEBI info)
PDQ Closed Trial Search ID 611933
PDQ Open Trial Search ID 611933 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039705

Other Properties:
     Name Value (qualifiers indented underneath)
code C78845
Contributing_Source CTRP
Legacy_Concept_Name Tetrodotoxin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78845

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