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Version: 16.11d (Release date: 2016-11-28)
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Ficlatuzumab (Code C78844)

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Terms & Properties

Preferred Name: Ficlatuzumab

Definition: A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF) with potential antineoplastic activity. Ficlatuzumab binds to the soluble ligand HGF, preventing the binding of HGF to its receptor c-Met and activation of the HGF/c-Met signaling pathway, which may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.

Display Name: Ficlatuzumab

Label: Ficlatuzumab

NCI Thesaurus Code: C78844 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703138  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-HGF Monoclonal Antibody SCH900105
AV-299
Ficlatuzumab
SCH 900105

External Source Codes: 
CAS Registry Number 1174900-84-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 610133
PDQ Open Trial Search ID 610133 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703138

Other Properties:
Name Value (qualifiers indented underneath)
code C78844
Contributing_Source CTRP
Legacy_Concept_Name Anti-HGF_Monoclonal_Antibody_SCH900105
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78844

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