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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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CD4+ CD25+ Regulatory T Cells (Code C78829)

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Terms & Properties

Preferred Name: CD4+ CD25+ Regulatory T Cells

Definition: Regulatory T cells that express CD4 and CD25 (interleukin 2 receptor) antigens, with immunomodulating activity. CD4+CD25+ T regulatory cells (Tregs), a subset of CD4+ T cells expressing high levels of CD25 and the transcription factor Foxp3, are essential in maintaining immunologic homeostasis, preventing autoimmunity by suppressing self-reactive T cells; CD4+CD25+ Tregs may induce tolerance to allogeneic organ transplants such as hematopoetic stem cell transplants (HSCTs).

NCI-GLOSS Definition: A type of immune cell that blocks the actions of some other types of lymphocytes, to keep the immune system from becoming over-active. T-regulatory cells are being studied in the treatment of cancer. A T-regulatory cell is a type of white blood cell and a type of lymphocyte.

Display Name: CD4+ CD25+ Regulatory T Cells

Label: CD4+ CD25+ Regulatory T Cells

NCI Thesaurus Code: C78829 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1267822  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD4+ CD25+ Regulatory T Cells
regulatory T cell
suppressor T cell
T-regulatory cell
T reg

External Source Codes: 
PDQ Closed Trial Search ID 601870
PDQ Open Trial Search ID 601870 (check for NCI PDQ open clinical trial info)
UMLS CUI C1267822

Other Properties:
     Name Value (qualifiers indented underneath)
code C78829
Contributing_Source CTRP
Legacy_Concept_Name CD4_CD25_Regulatory_T_Cells
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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