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Version: 17.06d (Release date: 2017-06-26)
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Idelalisib (Code C78825)

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Terms & Properties

Preferred Name: Idelalisib

Definition: An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.

Display Name: Idelalisib

Label: Idelalisib

NCI Thesaurus Code: C78825 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2698692  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H- quinazolin-4-one
CAL-101
GS-1101
GS 1101
Idelalisib
IDELALISIB
Phosphoinositide-3 Kinase Delta Inhibitor CAL-101
Zydelig

External Source Codes: 
CAS Registry Number 870281-82-6 (see NLM ChemIDplus info)
FDA UNII Code YG57I8T5M0
PDQ Closed Trial Search ID 601486
PDQ Open Trial Search ID 601486 (check for NCI PDQ open clinical trial info)
UMLS CUI C2698692

Other Properties:
     Name Value (qualifiers indented underneath)
code C78825
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PI3K-delta_Inhibitor_CAL-101
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78825

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