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Version: 17.06d (Release date: 2017-06-26)
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STAT3 Decoy Oligonucleotide (Code C78822)

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Terms & Properties

Preferred Name: STAT3 Decoy Oligonucleotide

Definition: A double-stranded 15-mer oligonucleotide, corresponding closely to the signal transducer and activator of transcription 3 (STAT3) response element within the c-fos promoter, with potential antineoplastic activity. STAT3 decoy oligonucleotide binds specifically to activated STAT3 and blocks binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters, which results in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck, contributing to the loss of cell growth control and neoplastic transformation.

Label: STAT3 Decoy Oligonucleotide

NCI Thesaurus Code: C78822 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387640  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
STAT3 Decoy
STAT3 Decoy ODN
STAT3 Decoy Oligonucleotide

External Source Codes: 
PDQ Closed Trial Search ID 601204
PDQ Open Trial Search ID 601204 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387640

Other Properties:
     Name Value (qualifiers indented underneath)
code C78822
Legacy_Concept_Name STAT3_Decoy_Oligonucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78822

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