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Version: 17.08d (Release date: 2017-08-28)
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Pyrimethamine (Code C788)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pyrimethamine

Definition: A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)

Display Name: Pyrimethamine

Label: Pyrimethamine

NCI Thesaurus Code: C788 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0034283  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Daraprim
Pyrimethamine
PYRIMETHAMINE

External Source Codes: 
CAS Registry Number 58-14-0 (see NLM ChemIDplus info)
FDA UNII Code Z3614QOX8W
ChEBI ID CHEBI:8673 (see ChEBI info)
NSC Code 3061 (see NCI DTP info)
PDQ Closed Trial Search ID 39578
PDQ Open Trial Search ID 39578 (check for NCI PDQ open clinical trial info)
UMLS CUI C0034283

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H13ClN4
code C788
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pyrimethamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C788

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