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National Cancer Institute
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Version: 17.04d (Release date: 2017-04-24)
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White Button Mushroom Extract (Code C78490)

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Terms & Properties

Preferred Name: White Button Mushroom Extract

Definition: A heat-stable extract of white button mushrooms (Agaricus bisporus) with potential chemopreventive and immunomodulating activities. Phytochemicals, such as polysaccharides and especially beta-D-glucans found in the white button mushroom extract, bind to and inhibit the activity of aromatase, an enzyme responsible for the conversion of androgens to estrogens and which is often upregulated in breast cancer cells. The consequent decrease in estrogen production may result in the suppression of estrogen-dependent cellular proliferation. In addition, this extract may promote dendritic cell (DC) maturation, increase interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) production, and may enhance natural killer (NK) cell activity, thus amplifying both innate and T cell-mediated immune responses against cancer cells.

Display Name: White Button Mushroom Extract

Label: White Button Mushroom Extract

NCI Thesaurus Code: C78490 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387508  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
WBM Extract
White Button Mushroom Extract

External Source Codes: 
PDQ Closed Trial Search ID 599759
PDQ Open Trial Search ID 599759 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387508

Other Properties:
     Name Value (qualifiers indented underneath)
code C78490
Contributing_Source CTRP
Legacy_Concept_Name White_Button_Mushroom_Extract
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78490

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