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Version: 16.10e (Release date: 2016-10-31)
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Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells (Code C78489)

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Terms & Properties

Preferred Name: Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells

Definition: A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T (NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis.

Label: Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells

NCI Thesaurus Code: C78489 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387518  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells
DC-KRN7000
KRN7000-Pulsed Autologous Dendritic Cells

External Source Codes: 
PDQ Closed Trial Search ID 600075
PDQ Open Trial Search ID 600075 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387518

Other Properties:
Name Value (qualifiers indented underneath)
code C78489
Legacy_Concept_Name Alpha-Galactosyl_Ceramide-Pulsed_Autologous_Dendritic_Cells
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78489

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