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Version: 16.10e (Release date: 2016-10-31)
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IL-2/Lptn Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine (Code C78487)

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Terms & Properties

Preferred Name: IL-2/Lptn Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine

Definition: A cancer vaccine consisting of allogeneic neuroblastoma tumor cells have been genetically modified to secrete the human cytokine interleukin-2 (IL-2) and the human chemokine lymphotactin (Lptn) with potential immunostimulating and antineoplastic activities. Upon administration, IL-2 and Lptn are secreted by the IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccine, potentially enhancing the cytotoxic T lymphocyte (CTL) response elicited by vaccine neuroblastoma tumor-associated antigens (TAAs) against host neuroblastoma tumor cells. Produced by activated progenitor T cells, Lptn belongs to the C chemokine subfamily and is a potent chemotactic factor for lymphocytes; IL-2 stimulates natural killer (NK) cells and may enhance a vaccine-elicited CTL immune response against tumor cells.

Display Name: IL-2/Lptn Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine

Label: IL-2/Lptn Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine

NCI Thesaurus Code: C78487 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387477  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL-2/Lptn Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine
IL-2/Lptn Loaded Allogeneic Neuroblastoma Cell Vaccine
Interleukin-2/Lymphotactin Gene-Modified Allogeneic Neuroblastoma Tumor Cell Vaccine
SJNB-JF-IL2 and SJNB-JF-Lptn Cells and SKNLP Unmodified Neuroblastoma Cell Lines

External Source Codes: 
PDQ Closed Trial Search ID 601127
PDQ Open Trial Search ID 601127 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387477

Other Properties:
Name Value (qualifiers indented underneath)
code C78487
Contributing_Source CTRP
Legacy_Concept_Name Interleukin-2_Lymphotactin_Gene-Modified_Allogeneic_Neuroblastoma_Tumor_Cell_Vaccine
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78487

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