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Version: 17.06d (Release date: 2017-06-26)
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Carbon C 11 Choline (Code C78485)

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Terms & Properties

Preferred Name: Carbon C 11 Choline

Definition: A radiotracer consisting of choline labeled with the positron-emitting isotope carbon C 11 with potential imaging use. Upon administration, C-11 choline incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, an enzyme frequently upregulated in human tumors, yielding phosphoryl C-11 choline. In turn, phosphoryl C-11 choline is integrated into phospholipids in the cell membrane as part of phosphatidylcholine. As the proliferation of cancer cells is much higher than normal cells, tumor cells exhibit an increased rate of C-11 choline uptake and incorporation, allowing tunor imaging with positron emission tomography (PET).

Display Name: Carbon C 11 Choline

Label: Carbon C 11 Choline

NCI Thesaurus Code: C78485 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2698585  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
C-11 Choline
C11 Choline
Carbon C 11 Choline
CHOLINE C-11
Ethanaminium, 2-hydroxy-N,N-dimethyl-N-(methyl-11C)-

External Source Codes: 
CAS Registry Number 94793-58-5 (see NLM ChemIDplus info)
FDA UNII Code M4AS4XGD4Q
PDQ Closed Trial Search ID 601057
PDQ Open Trial Search ID 601057 (check for NCI PDQ open clinical trial info)
UMLS CUI C2698585

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H14NO
code C78485
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name C-11_Choline
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78485

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