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Version: 17.12d (Release date: 2017-12-26)
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MET Tyrosine Kinase Inhibitor PF-04217903 (Code C78483)

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Terms & Properties

Preferred Name: MET Tyrosine Kinase Inhibitor PF-04217903

Definition: An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. The receptor tyrosine kinase c-Met, also known as hepatocyte growth factor (HGF) receptor, is overexpressed or mutated in many tumor cell types, playing an important role in tumor cell proliferation, survival, invasion, and metastasis and angiogenesis.

Display Name: MET Tyrosine Kinase Inhibitor PF-04217903

Label: MET Tyrosine Kinase Inhibitor PF-04217903

NCI Thesaurus Code: C78483 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703125  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MET Tyrosine Kinase Inhibitor PF-04217903

External Source Codes: 
CAS Registry Number 956905-27-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 601032
PDQ Open Trial Search ID 601032 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703125

Other Properties:
     Name Value (qualifiers indented underneath)
code C78483
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name MET_Tyrosine_Kinase_Inhibitor_PF-04217903
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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