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Version: 17.06d (Release date: 2017-06-26)
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Padeliporfin (Code C78481)

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Terms & Properties

Preferred Name: Padeliporfin

Definition: A vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll derivative with potential antineoplastic activity. Upon administration, paldeliporfin is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Vascular-targeted photodynamic therapy (VTP) with padeliporfin may allow tumor-site specific cytotoxicity while sparing adjacent normal tissues.

Display Name: Padeliporfin

Label: Padeliporfin

NCI Thesaurus Code: C78481 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387568  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Padeliporfin
PADELIPORFIN
Palladium-Bacteriochlorophyll Derivative WST11
WST11

External Source Codes: 
CAS Registry Number 759457-82-4 (see NLM ChemIDplus info)
FDA UNII Code EEO29FZT86
PDQ Closed Trial Search ID 600817
PDQ Open Trial Search ID 600817 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387568

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C37H43N5O9S.Pd
code C78481
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Palladium-Bacteriochlorophyll_Derivative_WST11
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78481

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