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Version: 17.06d (Release date: 2017-06-26)
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Ombrabulin (Code C78480)

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Terms & Properties

Preferred Name: Ombrabulin

Definition: A synthetic water-soluble analogue of combretastatin A4, derived from the South African willow bush (Combretum caffrum), with potential vascular-disrupting and antineoplastic activities. Ombrabulin binds to the colchicine binding site of endothelial cell tubulin, inhibiting tubulin polymerization and inducing mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis.

Display Name: Ombrabulin

Label: Ombrabulin

NCI Thesaurus Code: C78480 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0910081  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Combretastatin A4 Analogue AVE8062

External Source Codes: 
CAS Registry Number 181816-48-8 (see NLM ChemIDplus info)
FDA UNII Code 82JB1524Q6
PDQ Closed Trial Search ID 600816
PDQ Open Trial Search ID 600816 (check for NCI PDQ open clinical trial info)
UMLS CUI C0910081

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H26N2O6
code C78480
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Combretastatin_A4_Analogue_AVE8062
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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