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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 Fluoromethylcholine (Code C78479)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18 Fluoromethylcholine

Definition: A radiotracer consisting of methylcholine labeled with the positron-emitting radioisotope fluorine F 18 (18F-FMCH) with potential imaging use. Upon administration, 18F-fluoromethylcholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, an enzyme frequently upregulated in human tumors, yielding phosphoryl 18F-fluoromethylcholine. In turn, phosphoryl 18F-fluoromethylcholine is integrated into phospholipids in the cell membrane as part of phosphatidylcholine. As the proliferation of cancer cells is much higher than normal cells, tumor cells exhibit an increased rate of 18F-FMCH uptake and incorporation, allowing tumor imaging with positron emission tomography (PET).

Display Name: Fluorine F 18 Fluoromethylcholine

Label: Fluorine F 18 Fluoromethylcholine

NCI Thesaurus Code: C78479 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1870012  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-Fluoromethylcholine
Fluorine F 18 Fluoromethylcholine

External Source Codes: 
PDQ Closed Trial Search ID 600630
PDQ Open Trial Search ID 600630 (check for NCI PDQ open clinical trial info)
UMLS CUI C1870012

Other Properties:
     Name Value (qualifiers indented underneath)
code C78479
Contributing_Source CTRP
Legacy_Concept_Name _18F-Fluoromethylcholine
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78479

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