skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.10e (Release date: 2017-10-30)
SearchBox Top
SearchBox Bottom
Tigapotide (Code C78474)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tigapotide

Definition: A synthetic 15-mer peptide corresponding to amino acids 31-45 of the 94-amino acid isoform of human prostate secretory protein (PSP-94) with potential anti-metastasis and anti-angiogenesis activities. PSP-94-derived peptide PCK3145 may inhibit the secretion of the metastasis-related protein matrix metalloproteinase-9 (MMP-9) and its potential binding to its cell surface receptor CD44; may interfere with the vascular endothelial growth factor (VEGF) signaling pathway, resulting in an anti-angiogenesis effect; and may reduce the levels of parathyroid hormone-related protein (PTHrP), decreasing plasma calcium levels. PSP-94, one of three predominant proteins found in seminal fluid, may be down-regulated in prostate cancer, representing a potential survival mechanism for prostate cancer cells. MMP-9 is implicated in the invasion and metastasis of cancer. PTHrP may be expressed by various tumor cell types, resulting in the hypercalcemia of malignancy.

Label: Tigapotide

NCI Thesaurus Code: C78474 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1670100  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Prostate-Secretory Protein-94-Derived Peptide PCK3145

External Source Codes: 
CAS Registry Number 848084-83-3 (see NLM ChemIDplus info)
FDA UNII Code 1WZ6S45S94
PDQ Closed Trial Search ID 600185
PDQ Open Trial Search ID 600185 (check for NCI PDQ open clinical trial info)
UMLS CUI C1670100

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C82H119N21O34S3
code C78474
Contributing_Source FDA
Legacy_Concept_Name PSP-94-Derived_Synthetic_Peptide_PCK3145
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom