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Version: 17.06d (Release date: 2017-06-26)
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Testosterone Vaginal Cream (Code C78472)

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Terms & Properties

Preferred Name: Testosterone Vaginal Cream

Definition: A topical cream containing a synthetic form of the endogenous androgenic steroid testosterone. Upon vaginal application, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes. DHT binds with higher affinity to androgen receptors than testosterone, activating gene expression more efficiently. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Topical application of testosterone may improve symptoms of vaginal dryness.

Display Name: Testosterone Vaginal Cream

Label: Testosterone Vaginal Cream

NCI Thesaurus Code: C78472 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387584  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Testosterone Vaginal Cream

External Source Codes: 
PDQ Closed Trial Search ID 600085
PDQ Open Trial Search ID 600085 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387584

Other Properties:
     Name Value (qualifiers indented underneath)
code C78472
Contributing_Source CTRP
Legacy_Concept_Name Testosterone_Vaginal_Cream
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78472

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