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Version: 16.11d (Release date: 2016-11-28)
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PI3K Inhibitor GSK1059615 (Code C78470)

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Terms & Properties

Preferred Name: PI3K Inhibitor GSK1059615

Definition: A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor GSK1059615 inhibits PI3K in the PI3K/AKT kinase signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane and an increase in mitochondrial membrane permeability, followed by apoptosis. Bax is a member of the proapoptotic Bcl-2 family of proteins. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.

Display Name: PI3K Inhibitor GSK1059615

Label: PI3K Inhibitor GSK1059615

NCI Thesaurus Code: C78470 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387567  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GSK1059615
PI3K Inhibitor GSK1059615

External Source Codes: 
PDQ Closed Trial Search ID 600076
PDQ Open Trial Search ID 600076 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387567

Other Properties:
Name Value (qualifiers indented underneath)
code C78470
Contributing_Source CTRP
Legacy_Concept_Name PI3K_Inhibitor_GSK1059615
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78470

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