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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F-18 ML-10 (Code C78468)

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Terms & Properties

Preferred Name: Fluorine F-18 ML-10

Definition: A small molecular-weight, malonic acid-based probe [(2-(5-fluoro-pentyl)-2-methyl-malonic acid or ML-10] labeled with the radioactive isotope fluorine F 18 with potential apoptosis radioimaging use. Upon administration, [F18]-ML-10 binds selectively to apoptotic cells due to apoptotic cell membrane features that differ from those of normal, healthy and necrotic cell membranes. Upon entering the apoptotic cell, this agent accumulates within the cytoplasm where it can be imaged using positron emission tomography (PET). Detection of apoptotic cells using this imaging technology may be useful in monitoring tumor responses to cytotoxic therapies. ML-10 appears to mimic the alkyl-malonic acid motif present in gamma -carboxyglutamic (Gla), an amino acid that plays a crucial role in the binding of clotting factors to negatively-charged phospholipids exposed on the surfaces of apoptotic cells.

Display Name: Fluorine F-18 ML-10

Label: Fluorine F-18 ML-10

NCI Thesaurus Code: C78468 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387589  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[18F]-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-Acid
[18F]-ML-10
ApoSense ML-10
Fluorine F-18 ML-10
Fluorine F18-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-Acid
Fluorine F 18 ML-10

External Source Codes: 
PDQ Closed Trial Search ID 599996
PDQ Open Trial Search ID 599996 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387589

Other Properties:
     Name Value (qualifiers indented underneath)
code C78468
Contributing_Source CTRP
Legacy_Concept_Name _18F_2_5-Fluoro-Pentyl_2-Methyl-Malonic_Acid
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78468

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