skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
PGG Beta-Glucan (Code C78463)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PGG Beta-Glucan

Definition: An injectable formulation of the polysaccharide beta 1,3/1,6 glucan derived from the cell wall of the yeast Saccharomyces cerevisiae with potential immunomodulating and antineoplastic activities. PGG beta-glucan binds to an alternate site on the neutrophil complement receptor 3 (CR3), priming the neurophil to become cytotoxic when binding to complement on tumor cells via CR3. This agent has been reported to selectively activate immune cells without inducing pro-inflammatory cytokines, potentially reducing potential side effects observed with the induction of broad innate immune repsonses. In addition, PGG beta-glucan may induce hematopoietic progenitor cell (HPC) mobilization.

Display Name: PGG Beta-Glucan

Label: PGG Beta-Glucan

NCI Thesaurus Code: C78463 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387566  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Imprime PGG
PGG Beta-Glucan
Poly-(1-6)-beta-glucotriosyl-(1-3)-beta-glucopyranose Beta-glucan

External Source Codes: 
PDQ Closed Trial Search ID 599816
PDQ Open Trial Search ID 599816 (check for NCI PDQ open clinical trial info)
NCI META CUI CL387566

Other Properties:
Name Value (qualifiers indented underneath)
code C78463
Contributing_Source CTRP
Legacy_Concept_Name PGG_Beta-Glucan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78463

Mainbox Bottom