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Version: 17.10e (Release date: 2017-10-30)
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PGG Beta-Glucan (Code C78463)

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Terms & Properties

Preferred Name: PGG Beta-Glucan

Definition: An injectable formulation of the polysaccharide beta 1,3/1,6 glucan derived from the cell wall of the yeast Saccharomyces cerevisiae with potential immunomodulating and antineoplastic activities. PGG beta-glucan binds to an alternate site on the neutrophil complement receptor 3 (CR3), priming the neurophil to become cytotoxic when binding to complement on tumor cells via CR3. This agent has been reported to selectively activate immune cells without inducing pro-inflammatory cytokines, potentially reducing potential side effects observed with the induction of broad innate immune repsonses. In addition, PGG beta-glucan may induce hematopoietic progenitor cell (HPC) mobilization.

Display Name: PGG Beta-Glucan

Label: PGG Beta-Glucan

NCI Thesaurus Code: C78463 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387566  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Imprime PGG
PGG Beta-Glucan
Poly-(1-6)-beta-glucotriosyl-(1-3)-beta-glucopyranose Beta-glucan

External Source Codes: 
PDQ Closed Trial Search ID 599816
PDQ Open Trial Search ID 599816 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C78463
Contributing_Source CTRP
Legacy_Concept_Name PGG_Beta-Glucan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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