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Version: 17.12d (Release date: 2017-12-26)
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Talactoferrin Alfa (Code C78460)

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Terms & Properties

Preferred Name: Talactoferrin Alfa

Definition: An orally bioavailable recombinant human lactoferrin produced in the fungus Aspergillus niger with potential antineoplastic and immunomodulating activities. Upon oral administration, talactoferrin is transported into small intestinal Peyer's patches of the gut-associated lymphoreticular tissues (GALT), where it recruits circulating immature dendritic cells (DCs) bearing tumor antigens and induces their maturation. In the GALT, DC maturation in the presence of tumor antigens and lymphoid effector cells may induce systemic innate and adaptive immune responses mediated by anti-tumor natural killer (NK) cells, cytotoxic T lymphocytes, and natural killer T (NKT) cells; activation of tumor-draining lymph nodes, cellular infiltration of distant tumors, and tumor-cell death may follow. Raising the initial immune response in the GALT, distant from the primary tumor, may counter local tumor-mediated immunosuppression.

NCI-GLOSS Definition: A drug being studied in the treatment of kidney cancer that has spread. It is also being studied in the treatment of other types of cancer and other conditions. Talactoferrin increases the activity of dendritic cells (a type of immune cell) to help kill cancer cells. It is a form of human lactoferrin (a protein found in milk, tears, mucus, bile, and some white blood cells) that is made in the laboratory. Talactoferrin is a type of recombinant protein and a type of immunomodulatory protein.

Display Name: Talactoferrin Alfa

Label: Talactoferrin Alfa

NCI Thesaurus Code: C78460 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1872514  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oral Recombinant Human Lactoferrin
Oral rhLF
Talactoferrin Alfa
talactoferrin alfa

External Source Codes: 
CAS Registry Number 308240-58-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 394101
PDQ Open Trial Search ID 394101 (check for NCI PDQ open clinical trial info)
UMLS CUI C1872514

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For renal cell carcinoma
code C78460
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Talactoferrin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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