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Version: 17.12d (Release date: 2017-12-26)
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DI-Leu16-IL2 Immunocytokine (Code C78451)

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Terms & Properties

Preferred Name: DI-Leu16-IL2 Immunocytokine

Definition: A recombinant fusion protein consisting of de-immunized and humanized anti-CD20 monoclonal antibody Leu16 fused to human cytokine interleukin-2 (IL2) with potential antineoplastic activity. The antibody moiety of DI-Leu16-IL2 immunocytokine binds to tumor cells expressing the CD20 antigen, which may result in an antibody-dependent cell-mediated cytotoxicity (ADCC) towards CD20-expressing tumor cells; the localized IL2 moiety of this fusion protein may stimulate natural killer (NK) and T-lymphocyte mediated immune responses, enhancing the ADCC response. De-immunization involves the modification of potential helper T cell epitopes that bind to MHC class II molecules; humanization involves combining recombinant murine variable (V) regions with human immunoglobulin light and heavy chain constant regions. CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes, is overexpressed by various cancer cell types.

Display Name: DI-Leu16-IL2 Immunocytokine

Label: DI-Leu16-IL2 Immunocytokine

NCI Thesaurus Code: C78451 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL387463  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
De-Immunized Anti-CD20-IL-2 Immunocytokine DI-Leu16-IL-2
DI-Leu16-IL2 Immunocytokine

External Source Codes: 
PDQ Closed Trial Search ID 599668
PDQ Open Trial Search ID 599668 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C78451
Contributing_Source CTRP
Legacy_Concept_Name De-Immunized_DI-Leu16-IL2_Immunocytokine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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