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Version: 17.06d (Release date: 2017-06-26)
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Semuloparin (Code C78447)

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Terms & Properties

Preferred Name: Semuloparin

Definition: An ultralow-molecular-weight heparin (ULMWH) (Mw: 2000-3000 daltons)consisting of a polydisperse mixture of oligomeric heparin fragments with potential anticoagulant activity. Ultralow-molecular-weight heparin AVE5026 binds to and activates antithrombin III (ATIII), which may result in the inhibition of activated factor Xa and, to a much lesser extent, factor IIa (thrombin) and so the inhibition of fibrin formation. Compared to low-molecular-weight heparins (LMWHs), AVE5026 exhibits an even higher ratio of anti-Factor Xa to anti-Factor IIa activity (>30:1). Compared to unfractionated heparins, the use of LMWHs is associated with lower incidences of major bleeding, osteoporosis and heparin-induced thrombocytopenia. Like LMWHs, this agent may inhibit tumor growth by regulating angiogenesis and apoptosis. AVE5026 is prepared by partial depolymerization of unfractionated porcine mucosal heparin.

Display Name: Semuloparin

Label: Semuloparin

NCI Thesaurus Code: C78447 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2700104  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AVE-5026
AVE5026
Semuloparin
SEMULOPARIN
ULMW heparin AVE5026
Ultra-low-molecular-weight Heparin (2000-3000 MW; Phosphazene Depolymerization)
Ultralow-Molecular-Weight Heparin AVE5026

External Source Codes: 
CAS Registry Number 9005-49-6 (see NLM ChemIDplus info)
FDA UNII Code 4QW4AN84NQ
ChEBI ID CHEBI:28304 (see ChEBI info)
PDQ Closed Trial Search ID 599247
PDQ Open Trial Search ID 599247 (check for NCI PDQ open clinical trial info)
UMLS CUI C2700104

Other Properties:
     Name Value (qualifiers indented underneath)
code C78447
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ultralow-Molecular-Weight_Heparin_AVE5026
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78447

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