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Version: 17.06d (Release date: 2017-06-26)
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R-(-)-Gossypol Acetic Acid (Code C78348)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: R-(-)-Gossypol Acetic Acid

Definition: The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R-(-)-gossypol binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2 family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Racemic gossypol is a polyphenolic compound isolated from cottonseed.

Display Name: R-(-)-Gossypol Acetic Acid

Label: R-(-)-Gossypol Acetic Acid

NCI Thesaurus Code: C78348 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831824  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Gossypol Acetic Acid
(2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
R-(-)-Gossypol Acetic Acid

External Source Codes: 
CAS Registry Number 866541-93-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 594869
PDQ Open Trial Search ID 594869 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831824

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H30O8.C2H4O2
code C78348
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name R-Gossypol_Acetic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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