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Version: 17.06d (Release date: 2017-06-26)
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R-(-)-Gossypol Acetic Acid (Code C78348)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: R-(-)-Gossypol Acetic Acid

Definition: The orally bioavailable solvate of the R-(-) enantiomer of gossypol and acetic acid with potential antineoplastic activity. As a BH3 mimetic, R-(-)-gossypol binds to the hydrophobic surface binding groove BH3 of the anti-apoptotic proteins Bcl-2 and Bcl-xL, blocking their heterodimerization with pro-apoptotic members of the Bcl-2 family of proteins such as Bad, Bid, and Bim; this may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Racemic gossypol is a polyphenolic compound isolated from cottonseed.

Display Name: R-(-)-Gossypol Acetic Acid

Label: R-(-)-Gossypol Acetic Acid

NCI Thesaurus Code: C78348 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1831824  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-Gossypol Acetic Acid
(2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-(R)-5,5'-bis(1-methylethyl)-, (2R)-, compd. with acetic acid (1:1)
AT-101
GOSSYPOL ACETIC ACID, (R)-
R-(-)-Gossypol Acetic Acid

External Source Codes: 
CAS Registry Number 866541-93-7 (see NLM ChemIDplus info)
FDA UNII Code U9GNI6VT5N
PDQ Closed Trial Search ID 594869
PDQ Open Trial Search ID 594869 (check for NCI PDQ open clinical trial info)
UMLS CUI C1831824

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C30H30O8.C2H4O2
code C78348
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name R-Gossypol_Acetic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78348

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