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Version: 16.11d (Release date: 2016-11-28)
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Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes (Code C78201)

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Terms & Properties

Preferred Name: Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes

Definition: A preparation of cytotoxic T-lymphocytes (CTL), specifically reactive to the Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMC) are collected from a donor and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP1/2 to generate LMP1/2-specific CTL which are subsequently expanded. Administration of allogeneic LMP1-/LMP2- specific CTL to patients with LMP1/2-positive tumors may result in a specific CTL response against tumor cells expressing LMP1 and LMP2, resulting in cell lysis and inhibition of tumor cell proliferation. As tumor associated antigens (TAAs), LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.

Display Name: Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes

Label: Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes

NCI Thesaurus Code: C78201 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383592  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 595342
PDQ Open Trial Search ID 595342 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383592

Other Properties:
Name Value (qualifiers indented underneath)
code C78201
Contributing_Source CTRP
Legacy_Concept_Name Allogeneic_LMP1_LMP2-Specific_Cytotoxic_T-Lymphocytes
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78201

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