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Version: 17.06d (Release date: 2017-06-26)
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Alpha-Gal Glycosphingolipids (Code C78200)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Alpha-Gal Glycosphingolipids

Definition: A preparation of glycosphingolipids (GSL), containing the disaccharide epitope galactose-alpha-1,3-galactose (alpha-Gal), with potential antineoplastic activity. Upon intratumoral injection, alpha-Gal glycosphingolipids may stimulate the immune system to mount complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) responses against alpha-Gal GSL, which may result in tumor cell death; these responses involve natural anti-alpha-Gal immunoglobulins (Igs). As antibodies that occur naturally due to sensitization to alpha-Gal present on symbiotic bacterial flora, anti-alpha-Gal Igs are present in unusually high amounts in human sera. GSL represent a glycolipid subtype containing the amino alcohol sphingosine; tumor-associated GSL antigens contain various oligosaccharide residues.

Label: Alpha-Gal Glycosphingolipids

NCI Thesaurus Code: C78200 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383599  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha-Gal Glycosphingolipids
Galactose(alpha1,3,)galactose Glycosphingolipids
GSL alpha-GAL

External Source Codes: 
PDQ Closed Trial Search ID 595679
PDQ Open Trial Search ID 595679 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383599

Other Properties:
     Name Value (qualifiers indented underneath)
code C78200
Legacy_Concept_Name Alpha-Gal_Glycosphingolipids
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78200

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