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Version: 17.06d (Release date: 2017-06-26)
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FAK Inhibitor PF-00562271 (Code C78199)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: FAK Inhibitor PF-00562271

Definition: An orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. FAK inhibitor PF-00562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. As FAK is a signal transducer for integrins, inhibition of FAK by this agent may prevent integrin-mediated activation of several downstream signals including ERK, JNK/MAPK and PI3K/Akt. FAK and PYK2, upregulated in many tumor cell types, are involved in tumor cell invasion, migration and proliferation.

Label: FAK Inhibitor PF-00562271

NCI Thesaurus Code: C78199 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2703113  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FAK Inhibitor PF-00562271
Focal Adhesion Kinase Inhibitor PF-00562271
PF-00562271

External Source Codes: 
PDQ Closed Trial Search ID 595536
PDQ Open Trial Search ID 595536 (check for NCI PDQ open clinical trial info)
UMLS CUI C2703113

Other Properties:
     Name Value (qualifiers indented underneath)
code C78199
Legacy_Concept_Name FAK_Inhibitor_PF-00562271
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78199

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