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Version: 17.06d (Release date: 2017-06-26)
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Calaspargase Pegol (Code C78198)

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Terms & Properties

Preferred Name: Calaspargase Pegol

Definition: An intravenous formulation containing E.coli-derived L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol (SC-PEG), with potential antineoplastic activity. L-asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cells of asparagine; asparagine depletion blocks protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle and ultimately induces tumor cell death. Asparagine is critical to protein synthesis in acute lymphoblastic leukemia (ALL) cells which, unlike normal cells, cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Pegylation decreases enzyme antigenicity and increases its half life. SC is used as a PEG linker to facilitate attachment to asparaginase and enhances the stability of the formulation.

NCI-GLOSS Definition: A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the anticancer drug PEG-asparaginase that stays in the body longer. EZN-2285 is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor.

Display Name: Calaspargase Pegol

Label: Calaspargase Pegol

NCI Thesaurus Code: C78198 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2699709  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Calaspargase Pegol
EZN-2285
Oncaspar-IV
SC-PEG E. coli L-asparaginase
SC-PEG E. Coli L-Asparaginase
Succinimidyl Carbonate Monomethoxypolyethylene Glycol E. coli L-Asparaginase

External Source Codes: 
CAS Registry Number 941577-06-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 595298
PDQ Open Trial Search ID 595298 (check for NCI PDQ open clinical trial info)
UMLS CUI C2699709

Other Properties:
     Name Value (qualifiers indented underneath)
code C78198
Contributing_Source CTRP
Legacy_Concept_Name Succinimidyl_Carbonate_Monomethoxypolyethylene_Glycol_E_Coli_L-Asparaginase
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78198

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