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Version: 17.06d (Release date: 2017-06-26)
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Docetaxel Emulsion ANX-514 (Code C78196)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Docetaxel Emulsion ANX-514

Definition: An injectable emulsion formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Docetaxel emulsion ANX-514 is formulated without polysorbate 80 or other detergents in order to reduce the incidence and severity of hypersensitivity reactions. In addition, the exclusion of polysorbate 80 in this formulation precludes foaming during the preparation process, thus facilitating preparation and administration.

Display Name: Docetaxel Emulsion ANX-514

Label: Docetaxel Emulsion ANX-514

NCI Thesaurus Code: C78196 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383589  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ANX-514
Docetaxel Emulsion ANX-514

External Source Codes: 
PDQ Closed Trial Search ID 595290
PDQ Open Trial Search ID 595290 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383589

Other Properties:
     Name Value (qualifiers indented underneath)
code C78196
Contributing_Source CTRP
Legacy_Concept_Name Docetaxel_Emulsion_ANX-514
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78196

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