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Version: 17.06d (Release date: 2017-06-26)
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Ponatinib Hydrochloride (Code C78194)

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Terms & Properties

Preferred Name: Ponatinib Hydrochloride

Definition: The hydrochloride salt form of an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome.

Display Name: Ponatinib Hydrochloride

Label: Ponatinib Hydrochloride

NCI Thesaurus Code: C78194 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AP24534 HCl
Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1- Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl)-, Hydrochloride (1:1)
Iclusig
Ponatinib Hydrochloride
PONATINIB HYDROCHLORIDE

External Source Codes: 
CAS Registry Number 1114544-31-8 (see NLM ChemIDplus info)
FDA UNII Code 96R6PU3D8J
PDQ Closed Trial Search ID 595060
PDQ Open Trial Search ID 595060 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981174

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H27F3N6O.ClH
code C78194
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Multitargeted_Receptor_Tyrosine_Kinase_Inhibitor_AP24534
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C78194

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