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Version: 17.06d (Release date: 2017-06-26)
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Ponatinib Hydrochloride (Code C78194)

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Terms & Properties

Preferred Name: Ponatinib Hydrochloride

Definition: The hydrochloride salt form of an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome.

Display Name: Ponatinib Hydrochloride

Label: Ponatinib Hydrochloride

NCI Thesaurus Code: C78194 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2981174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AP24534 HCl
Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1- Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl)-, Hydrochloride (1:1)
Ponatinib Hydrochloride

External Source Codes: 
CAS Registry Number 1114544-31-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 595060
PDQ Open Trial Search ID 595060 (check for NCI PDQ open clinical trial info)
UMLS CUI C2981174

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H27F3N6O.ClH
code C78194
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Multitargeted_Receptor_Tyrosine_Kinase_Inhibitor_AP24534
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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