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Version: 17.06d (Release date: 2017-06-26)
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Ribosome-Inactivating Protein CY503 (Code C78188)

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Terms & Properties

Preferred Name: Ribosome-Inactivating Protein CY503

Definition: A recombinant protein that inactivates the ribosome with potential antineoplastic and immunomodulating activities. Ribosome-inactivating protein CY503 binds to the cell surface sialyltransferase CD75 and is internalized; intracellularly, CY503 cleaves an adenine-specific N-glycosidic bond on the 28S ribosomal subunit, which may result in tumor cell apoptosis. This agent has also been shown to activate natural killer (NK) cells, induce cytokine receptor expression, and stimulate the release of cytokines. CD75 is expressed on mature B-cells and subsets of T-cells and erythrocytes.

Label: Ribosome-Inactivating Protein CY503

NCI Thesaurus Code: C78188 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383580  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ribosome-Inactivating Protein CY503

External Source Codes: 
PDQ Closed Trial Search ID 594770
PDQ Open Trial Search ID 594770 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C78188
Legacy_Concept_Name Ribosome-Inactivating_Protein_CY503
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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